PXI-6221

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16 AI (16-Bit, 25 kS/s), 2 AO, 24 DIO, PXI Multifunction I/O Module

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National Instruments PXI-6221 M Series Multifunction DAQ Module, 16 Analog Inputs, 16-Bit, 250 kS/s for PXI Test Systems

Product Introduction

The NI PXI-6221 is an M Series multifunction data acquisition (DAQ) module designed for automated testing, laboratory measurement, industrial monitoring, sensor acquisition, and general-purpose PXI measurement systems. It combines analog input, analog output, digital I/O, and counter/timer functionality in a single modular instrument.

Featuring 16 single-ended or 8 differential analog inputs, 16-bit resolution, a maximum aggregate analog input sampling rate of 250 kS/s, two analog outputs, 24 digital I/O lines, and two 32-bit counter/timers, the PXI-6221 provides a versatile solution for multifunction data acquisition and control applications.

Product Overview

The NI PXI-6221 belongs to the NI M Series multifunction DAQ family and is designed to consolidate multiple measurement and control functions into a single PXI module.

Its analog input subsystem supports up to 16 single-ended or 8 differential measurement channels with 16-bit resolution. The multiplexed acquisition architecture provides an aggregate sampling rate of up to 250 kS/s, making the module suitable for general-purpose voltage acquisition, sensor measurements, electronic validation, and automated data logging.

Unlike input-focused DAQ modules such as the PXI-6225, the PXI-6221 also provides two analog output channels. Combined with digital I/O and counter/timer resources, this enables the module to perform stimulus, measurement, control, and timing functions within the same PXI test system.

Key Features

16 Analog Input Channels

The PXI-6221 provides flexible analog input configurations for general-purpose voltage and sensor measurements.

  • 16 single-ended analog inputs
  • 8 differential analog inputs
  • Multi-channel voltage acquisition
  • Sensor signal measurement
  • Automated data logging

Advantage: The configurable input architecture allows engineers to balance channel count and differential measurement requirements according to the application.

16-Bit Analog Input Resolution

The PXI-6221 uses 16-bit analog-to-digital conversion for general-purpose measurement applications.

  • 16-bit ADC resolution
  • Voltage signal acquisition
  • Sensor measurements
  • Electronic characterization
  • Repeatable automated measurements

Advantage: Provides suitable measurement resolution for a broad range of laboratory, industrial, and automated test applications.

250 kS/s Analog Input Sampling

The PXI-6221 supports a maximum aggregate analog input sampling rate of up to 250 kS/s.

  • Up to 250 kS/s aggregate sampling
  • Hardware-timed acquisition
  • Multi-channel data acquisition
  • Waveform monitoring
  • Automated measurement applications

Advantage: Provides a practical combination of acquisition speed and multifunction capability for general-purpose PXI test systems.

Multiplexed Analog Input Architecture

The PXI-6221 uses a multiplexed analog input architecture in which multiple input channels share the analog-to-digital conversion subsystem.

  • Efficient multi-channel acquisition
  • Sequential channel scanning
  • Flexible channel configuration
  • Compact multifunction architecture
  • General-purpose measurement capability

Advantage: Multiplexing enables multiple analog input channels to be integrated economically into a compact multifunction PXI module.

2 Analog Output Channels

In addition to analog acquisition, the PXI-6221 provides two analog output channels for generating programmable voltage signals.

  • 2 analog output channels
  • 16-bit analog output resolution
  • Programmable voltage generation
  • Stimulus generation
  • Closed-loop test applications

Advantage: Analog input and output functionality can be combined within one module for stimulus-and-response testing and basic control applications.

24 Digital I/O Lines

The PXI-6221 provides 24 digital I/O lines for interfacing with external digital devices, test fixtures, and control hardware.

  • 24 digital I/O lines
  • Digital input monitoring
  • Digital output control
  • Test fixture interfacing
  • Device status monitoring

Advantage: Digital control functions can be integrated with analog acquisition and generation without requiring a separate general-purpose digital I/O module.

Two 32-Bit Counter/Timers

The PXI-6221 includes two 32-bit counter/timers for hardware-timed measurement and generation applications.

  • Event counting
  • Frequency measurement
  • Period measurement
  • Pulse-width measurement
  • Pulse generation
  • Encoder-related measurements

Advantage: Counter/timer resources extend the module’s functionality beyond conventional analog and digital data acquisition.

Hardware Timing and Triggering

The PXI-6221 supports hardware timing and triggering for repeatable automated measurement sequences.

  • Hardware-timed analog acquisition
  • External triggering
  • Sample clock control
  • PXI trigger integration
  • Coordinated measurement sequences

Advantage: Hardware timing provides more deterministic and repeatable measurements than software-timed acquisition alone.

PXI System Integration

The PXI-6221 can be installed alongside other PXI instruments to create complete automated test and measurement systems.

  • PXI modular architecture
  • Multi-instrument integration
  • Shared PXI triggering resources
  • Compact test system design
  • Scalable measurement architecture

Advantage: Engineers can combine multifunction DAQ with switching, DMM, oscilloscope, signal generation, communication, and timing modules within a unified PXI platform.

NI-DAQmx Software Support

The PXI-6221 is supported by NI-DAQmx for hardware configuration, acquisition, generation, timing, triggering, and application development.

  • NI-DAQmx support
  • LabVIEW integration
  • NI MAX configuration
  • TestStand integration
  • C/C++ and .NET development

Advantage: Provides an established software ecosystem for developing customized data acquisition and automated test applications.

Technical Specifications

ParameterDescription
Product TypePXI M Series Multifunction DAQ Module
Analog Input Channels16 Single-Ended / 8 Differential
Analog Input Resolution16-bit
Maximum Analog Input Sample Rate250 kS/s Aggregate
Analog Input ArchitectureMultiplexed
Maximum Analog Input Range±10 V
Analog Output Channels2
Analog Output Resolution16-bit
Analog Output Range±10 V
Digital I/O24 Lines
Counter/Timers2, 32-bit
TimingHardware Timed
TriggeringAnalog and Digital Triggering Support
Bus PlatformPXI
Product FamilyNI M Series Multifunction DAQ
DriverNI-DAQmx
Primary ApplicationsMultifunction DAQ, Automated Test, Sensor Measurement and Laboratory Data Acquisition

Software Ecosystem

The NI PXI-6221 integrates with NI software tools for measurement configuration, data acquisition, signal generation, analysis, visualization, and automated testing.

  • NI-DAQmx: Provides configuration and programming APIs for analog input, analog output, digital I/O, counters, timing, and triggering.
  • LabVIEW: Enables development of customized acquisition, control, visualization, data logging, and automated measurement applications.
  • NI MAX: Provides hardware detection, configuration, self-test, diagnostics, and basic hardware testing.
  • TestStand: Enables PXI-6221 measurements and control functions to be incorporated into automated validation and production test sequences.
  • C/C++ and .NET: Support customized test and measurement application development through compatible NI-DAQmx APIs.

Industries

  • Automated Test
  • Electronic Manufacturing
  • Industrial Automation
  • Automotive Testing
  • Aerospace and Defense
  • Electromechanical Testing
  • Research and Development
  • Scientific Laboratories

Applications

General-Purpose Data Acquisition

The PXI-6221 provides a balanced combination of analog, digital, and timing resources for general-purpose PXI data acquisition.

  • Voltage acquisition
  • Multi-channel measurements
  • Data logging
  • Laboratory instrumentation

Automated Electronic Testing

The multifunction architecture makes the PXI-6221 suitable for automated electronic validation and production test systems.

  • Functional testing
  • Electronic subsystem validation
  • Production testing
  • Automated measurement sequences

Stimulus and Response Testing

The combination of analog input and analog output enables the PXI-6221 to generate test signals and measure resulting responses.

  • Programmable voltage stimulus
  • Device response measurement
  • Component characterization
  • Automated functional testing

Sensor Measurement

When paired with appropriate sensors and signal conditioning, the PXI-6221 can acquire a variety of physical measurement signals.

  • Pressure measurement
  • Position measurement
  • Force and load measurement
  • General-purpose transducer acquisition

Industrial Monitoring and Control

Analog input, analog output, digital I/O, and counter resources allow the PXI-6221 to perform measurement and basic control functions.

  • Machine monitoring
  • Process measurement
  • Equipment diagnostics
  • Automated control systems

Counter and Frequency Measurement

The integrated counter/timers can be used for digital timing and event measurement applications.

  • Frequency measurement
  • Event counting
  • Period measurement
  • Pulse-width measurement
  • Encoder measurements

Research and Laboratory Measurement

The PXI-6221 provides a programmable multifunction measurement platform for engineering and scientific laboratories.

  • Experimental data acquisition
  • Prototype characterization
  • Automated laboratory testing
  • Engineering research

Comparison with Similar PXI DAQ Modules

ModelMain DifferenceBest Application
NI PXI-6221 16-bit multifunction M Series DAQ with 16 single-ended analog inputs, two analog outputs, digital I/O, and counter/timers. General-purpose multifunction data acquisition
NI PXI-6225 High-channel-count M Series DAQ providing up to 80 single-ended analog inputs for systems requiring significantly more measurement channels. High-density analog input acquisition
NI PXI-6251 Higher-performance M Series multifunction DAQ with faster analog input sampling for more demanding automated measurement applications. Higher-speed general-purpose multifunction DAQ
NI PXI-6280 High-accuracy M Series DAQ featuring 18-bit analog input resolution for applications prioritizing precision. High-accuracy analog measurement

Recommended Related Products

NI PXI-6225 High-channel-count M Series DAQ module for applications requiring substantially more analog measurement channels.
NI PXI-6251 Higher-performance multifunction DAQ module for applications requiring faster analog acquisition and broader measurement capability.
NI PXI-6280 18-bit high-accuracy multifunction DAQ module for precision voltage and sensor measurement applications.
NI PXI-6722 Dedicated PXI analog output module for systems requiring a larger number of programmable analog output channels.

Why Choose PXI-6221?

  • 16 single-ended or 8 differential analog inputs
  • 16-bit analog input resolution
  • Up to 250 kS/s aggregate analog input sampling
  • 2 analog output channels
  • 24 digital I/O lines
  • Two 32-bit counter/timers
  • Hardware timing and triggering
  • PXI modular system integration
  • NI-DAQmx and LabVIEW support
  • Suitable for measurement, stimulus, control, and automated testing

Frequently Asked Questions

What is the NI PXI-6221?

The NI PXI-6221 is an M Series multifunction PXI data acquisition module that combines analog input, analog output, digital I/O, and counter/timer functionality for automated test and general-purpose measurement applications.

How many analog input channels does the PXI-6221 have?

The PXI-6221 provides up to 16 single-ended analog input channels or 8 differential analog input channels.

What is the analog input resolution of the PXI-6221?

The PXI-6221 provides 16-bit analog input resolution, making it suitable for general-purpose voltage, sensor, laboratory, and automated test measurements.

What is the maximum sampling rate of the PXI-6221?

The PXI-6221 supports a maximum aggregate analog input sampling rate of 250 kS/s. Because the module uses a multiplexed analog input architecture, this specification should not be interpreted as a simultaneous 250 kS/s rate for every analog input channel.

Does the PXI-6221 have analog outputs?

Yes. The PXI-6221 provides two 16-bit analog output channels, allowing the module to generate programmable voltage signals for stimulus, control, and automated test applications.

How many digital I/O lines does the PXI-6221 provide?

The PXI-6221 provides 24 digital I/O lines for interfacing with external devices, monitoring digital states, controlling test fixtures, and implementing automated test logic.

Does the PXI-6221 include counter/timers?

Yes. The PXI-6221 provides two 32-bit counter/timers that can be used for event counting, frequency measurement, period measurement, pulse-width measurement, pulse generation, and related timing applications.

What is the difference between PXI-6221 and PXI-6225?

The PXI-6221 is a general-purpose multifunction DAQ module with 16 single-ended analog inputs and two analog outputs. The PXI-6225 is designed primarily for high-channel-count acquisition and provides up to 80 single-ended analog inputs but does not provide onboard analog outputs. The PXI-6221 is therefore more suitable when multifunction input and output capability is required, while the PXI-6225 is better suited to systems prioritizing analog input channel density.

What is the difference between PXI-6221 and PXI-6251?

Both belong to the NI M Series multifunction DAQ family. The PXI-6221 provides up to 250 kS/s aggregate analog input sampling, while the PXI-6251 offers higher analog acquisition performance. The PXI-6221 is suitable for general-purpose applications where moderate sampling speed is sufficient, while the PXI-6251 is preferable for faster measurement requirements.

What software supports the PXI-6221?

The PXI-6221 is supported by NI-DAQmx and can be integrated with LabVIEW, NI MAX, TestStand, and compatible C/C++ and .NET development environments.

Conclusion

The NI PXI-6221 M Series multifunction DAQ module provides a balanced solution for automated data acquisition, signal generation, digital control, timing, and laboratory measurement. With 16 single-ended or 8 differential analog inputs, 16-bit resolution, up to 250 kS/s aggregate sampling, two analog outputs, 24 digital I/O lines, two 32-bit counter/timers, hardware timing, and NI-DAQmx support, the PXI-6221 is well suited for general-purpose PXI automated test and measurement systems.

Specifications

Brand

National Instruments

Condition

Used

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